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Examining the association between maternal analgesic use during pregnancy and risk of psychotic symptoms during adolescence

Gunawardana, Lihini, Zammit, Stanley, Lewis, Glyn, Gunnell, David, Hollis, Chris, Wolke, Dieter and Harrison, Glynn 2011. Examining the association between maternal analgesic use during pregnancy and risk of psychotic symptoms during adolescence. Schizophrenia Research 126 (1-3) , pp. 220-225. 10.1016/j.schres.2010.10.021

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Background: Children and adolescents who report psychotic symptoms in non-clinical samples are at an increased risk of developing schizophrenia. Study of such ‘high risk’ groups may increase our understanding of early risk factors for psychotic illnesses. Maternal infection during pregnancy is associated with an increased risk of schizophrenia in the offspring, and it has been hypothesised that exposure to maternal intake of analgesics during pregnancy, taken to alleviate the symptoms of viral infections, may partly explain this association. The aim of this study was to examine the relationship between maternal use of aspirin and other analgesics during pregnancy and the occurrence of psychotic symptoms in the offspring. Methods: This was a longitudinal study of 6437 children belonging to the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort who participated in the psychosis-likesymptoms semi-structured interview (PLIKSi) at 12 years of age. Data on in-utero exposure to analgesics were obtained from self-report questionnaires completed by the mothers during pregnancy. Results: Increasing frequency of aspirin use during pregnancy was associated with an increased risk of psychotic experiences (adjusted OR 1.44, 95% CI 1.08–1.92). Risk was highest in those whose mothers used aspirin most days or daily (adjusted OR 2.79, 95% CI 1.27–6.07). Paracetamol and other analgesic use during pregnancy were not associated with the risk of offspring psychotic symptoms. Conclusions: Medications such as aspirin that interfere with the prostaglandin pathway, taken during pregnancy, may influence the risk of schizophrenia in the offspring. Other epidemiological studies are needed to examine this association further. © 2010 Elsevier B.V. All rights reserved.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RG Gynecology and obstetrics
Uncontrolled Keywords: Aspirin; Psychotic symptoms; Pregnancy; Prostaglandins; ALSPAC
Publisher: Elsevier
ISSN: 0920-9964
Last Modified: 04 Jun 2017 03:43

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