Monocytes and γδ T cells: close encounters in microbial infection

Eberl, Matthias ORCID: https://orcid.org/0000-0002-9390-5348 and Moser, Bernhard ORCID: https://orcid.org/0000-0002-4354-4572 2009. Monocytes and γδ T cells: close encounters in microbial infection. Trends in Immunology 30 (12) , pp. 562-568. 10.1016/j.it.2009.09.001

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Abstract

γδ T cells comprise an evolutionarily conserved yet poorly understood subset of T cells. Numerous features place these unconventional lymphocytes at the branching point between antigen-presenting cells and natural killer cells of the innate immune system and major-histocompatibility-complex-restricted αβ T cells of the adaptive immune system. We propose a role for human Vγ9/Vδ2 T cells in the generation of monocyte-derived inflammatory dendritic cells during infection. Our model incorporates the peculiar innate-like specificity of Vγ9/Vδ2 T cells for the microbial metabolite (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP), co-recruitment of monocytes and Vγ9/Vδ2 T cells to sites of infection, and their crosstalk, with profound consequences for the initiation of antigen-specific αβ T-cell responses. Vγ9/Vδ2 T cells act thus as a cellular switch between innate and adaptive defence mechanisms.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > R Medicine (General)
Publisher:	Elsevier
ISSN:	1471-4906
Last Modified:	19 Oct 2022 10:48
URI:	https://orca.cardiff.ac.uk/id/eprint/25548

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