The effect of age and the H1c MAPT haplotype on MAPT expression in human brain

Hayesmoore, Jesse B. G., Bray, Nicholas John ORCID: https://orcid.org/0000-0002-4357-574X, Cross, William C., Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862, O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379 and Morris, Huw Rees 2009. The effect of age and the H1c MAPT haplotype on MAPT expression in human brain. Neurobiology of Aging 30 (10) , pp. 1652-1656. 10.1016/j.neurobiolaging.2007.12.017

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Abstract

The MAPT H1c haplotype is a risk factor for the neurodegenerative tauopathies progressive supranuclear palsy (PSP) and Alzheimer's disease. We hypothesise that the effect of the H1c haplotype relates to an increase in MAPT expression leading to an increase in tau neurofibrillary tangle deposition. We have evaluated the effect of the MAPT H1c haplotype on the expression of MAPT using allele specific expression, comparing the relative levels of MAPT H1 and H2 RNA derived from post-mortem human brain, unaffected by neurodegenerative disease. Using three assays spanning the MAPT gene we did not detect any effect of H1c on MAPT expression as compared with other haplotypes. We did, however, detect an effect of age on expression of MAPT H1 with a relative decrease in MAPT H1 expression with increased age. Our data suggest that there is an interaction between age and the expression of MAPT.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	Tau; MAPT; Expression; PSP; H1c haplotype
Publisher:	Elsevier
ISSN:	0197-4580
Last Modified:	06 Dec 2022 09:45
URI:	https://orca.cardiff.ac.uk/id/eprint/25704

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