A paradoxical difference in relationship between anxiety, depression and thyroid function in subjects on and not on T4: findings from the HUNT study

Panicker, Vijay, Evans, Jonathan, Bjøro, Trine, Åsvold, Bjorn O., Dayan, Colin Mark ORCID: https://orcid.org/0000-0002-6557-3462 and Bjerkeset, Ottar 2009. A paradoxical difference in relationship between anxiety, depression and thyroid function in subjects on and not on T4: findings from the HUNT study. Clinical Endocrinology 71 (4) , pp. 574-580. 10.1111/j.1365-2265.2008.03521.x

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Abstract

Objective There have been conflicting reports on the relationship between thyroid function and mood between studies in subjects on T4 and the general population not on T4. We investigated this relationship in a large catchment area-based study. Design We analysed data on serum TSH levels and Hospital Anxiety and Depression Scale (HADS) scores fromtheHUNT 2 study (age ‡ 40 years). Following a test for interaction, analyses were performed separately in females on T4 (n ¼ 1265) and in people not on T4 (males n ¼ 9319 and females n ¼ 17 694). Results More females on T4 had high depression and anxiety scores than females not on T4 (depression 18Æ4% vs. 13Æ0%, P < 0Æ001, anxiety 23Æ4% vs. 18Æ7%, P < 0Æ001). In those not on T4, there was an inverse association between serum TSH and depression score in males (B coefficient ¼ –0Æ61, 95% CI –0Æ91 to –0Æ24, P ¼ 0Æ001) though not in females (B coefficient ¼ –0Æ07, –0Æ33 to 0Æ19), and an inverse association between TSH and anxiety score in both genders (B coefficient for males ¼ 0Æ68, 95% CI –1Æ04 to –0Æ32, P < 0Æ001; females –0Æ37, 95% CI –0Æ67 to –0Æ08, P ¼ 0Æ01). In contrast, in females on T4, TSH was positively associated with both depression (B coefficient¼ +0Æ27, 95%CI 0Æ02 to 0Æ51, P < 0Æ05)and anxiety (B coefficient ¼ +0Æ29, 95% CI 0Æ01 to 0Æ56, P < 0Æ05). Conclusions There is a different relationship between thyroid function and depression and anxiety in females on T4 compared with individuals with no thyroid disease. This group also has a higher prevalence of depression and anxiety.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Blackwell Publishing
ISSN:	0300-0664
Last Modified:	20 Oct 2022 07:46
URI:	https://orca.cardiff.ac.uk/id/eprint/26370

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