Polarity at illness onset in bipolar I disorder and clinical course of illness

Forty, Elizabeth, Jones, Lisa, Jones, Ian Richard ORCID: https://orcid.org/0000-0001-5821-5889, Smith, Daniel J., Caesar, Sian, Fraser, Christine, Gordon-Smith, Katherine, Hyde, Sally and Craddock, Nicholas John ORCID: https://orcid.org/0000-0003-2171-0610 2009. Polarity at illness onset in bipolar I disorder and clinical course of illness. Bipolar Disorders 11 (1) , pp. 82-88. 10.1111/j.1399-5618.2008.00654.x

Full text not available from this repository.

Abstract

Objectives: Studies have suggested that episode polarity at illness onset in bipolar disorder may be predictive of some aspects of lifetime clinical characteristics. We here examine this possibility in a large, well-characterized sample of patients with bipolar I disorder. Methods: We assessed polarity at onset in patients with bipolar I disorder (N = 553) recruited as part of our ongoing studies of affective disorders. Lifetime clinical characteristics of illness were compared in patients who had a depressive episode at first illness onset (n = 343) and patients who had a manic episode at first illness onset (n = 210). Results: Several lifetime clinical features differed between patients according to the polarity of their onset episode of illness. A logistic regression analysis showed that the lifetime clinical features significantly associated with a depressive episode at illness onset in our sample were: an earlier age at illness onset; a predominantly depressive polarity during the lifetime; more frequent and more severe depressive episodes; and less prominent lifetime psychotic features. Conclusions: Knowledge of pole of onset may help the clinician in providing prognostic information and management advice to an individual with bipolar disorder.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	affective disorder, bipolar disorder, depression, mania, onset polarity
Publisher:	Wiley
ISSN:	1398-5647
Last Modified:	20 Oct 2022 07:49
URI:	https://orca.cardiff.ac.uk/id/eprint/26495

Citation Data

Cited 49 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item