Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Reduced movement-related beta desynchronisation in juvenile myoclonic epilepsy: A MEG study of task specific cortical modulation

Hamandi, Khalid, Singh, Krish Devi ORCID: https://orcid.org/0000-0002-3094-2475 and Muthukumaraswamy, Suresh Daniel ORCID: https://orcid.org/0000-0001-7042-3920 2011. Reduced movement-related beta desynchronisation in juvenile myoclonic epilepsy: A MEG study of task specific cortical modulation. Clinical Neurophysiology 122 (11) , pp. 2128-2138. 10.1016/j.clinph.2011.04.017

Full text not available from this repository.

Abstract

Objective We investigated differences in task induced responses in occipital and sensorimotor cortex between patients with juvenile myclonic epilepsy (JME) and healthy controls . Methods Twelve patients with JME and 12 age-matched non-epilepsy volunteers performed visual and motor tasks during MEG. We used synthetic aperture magnetometry to localise areas of task-related oscillatory modulations, performed time–frequency analyses on the locations of peak task related power changes and compared power and frequency modulation at these locations between patients and controls. Results Patients with JME had significantly reduced pre-movement beta event-related desynchronisation in the motor task compared to controls. No significant differences were seen in other motor-related responses, or visual oscillatory responses. Conclusions Altered beta event-related desynchronisation may represent network specific dysfunction in JME possibly through GABAergic dysfunction. Significance Characterising task specific cortical responses in epilepsy offers the potential to understand the patho-physiological basis of seizures and provide a window on disease and treatment effects.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Cardiff University Brain Research Imaging Centre (CUBRIC)
Psychology
Neuroscience and Mental Health Research Institute (NMHRI)
Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Juvenile myoclonic epilepsy, JME, Magnetoencephalography, MEG, Beamformer
Publisher: Elsevier
ISSN: 1388-2457
Last Modified: 20 Oct 2022 07:52
URI: https://orca.cardiff.ac.uk/id/eprint/26765

Citation Data

Cited 14 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item