Acute lung injury in preterm newborn infants: mechanisms and management

Chakraborty, Mallinath, McGreal, Eamon Patrick and Kotecha, Sailesh ORCID: https://orcid.org/0000-0003-3535-7627 2010. Acute lung injury in preterm newborn infants: mechanisms and management. Paediatric Respiratory Reviews 11 (3) , pp. 162-170. 10.1016/j.prrv.2010.03.002

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Abstract

Respiratory morbidity and mortality remain common in preterm infants. The immature pretermlung is especially prone to injury. This process often starts in-utero due to maternal chorioamnionitis, priming the lung for further injury in response to post-natal ventilation, oxygen and nosocomial infection. Pulmonary inflammation has been strongly implicated in the pathway leading to lunginjury in this population of infants. Several therapeutic approaches have been attempted to prevent acutelunginjury or to limit its progress. The mechanisms of acutelunginjury in preterm infants; their clinical correlates and available therapeutic approaches are reviewed here.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
Uncontrolled Keywords:	Premature birth; Infant; Acutelunginjury; Inflammation; Bronchopulmonary dysplasia; Chronic lung disease of prematurity; Respiratory distress syndrome
Publisher:	Elsevier
ISSN:	1526-0542
Last Modified:	06 Feb 2023 15:29
URI:	https://orca.cardiff.ac.uk/id/eprint/27512

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