Further analysis of previously implicated linkage regions for Alzheimer's disease in affected relative pairs

Blom, Elin S., Giedraitis, Vilmantas, Arepalli, Sampath, Hamshere, Marian Lindsay ORCID: https://orcid.org/0000-0002-8990-0958, Adighibe, Omanma, Goate, Alison, Williams, Julie ORCID: https://orcid.org/0000-0002-4069-0259, Lannfelt, Lars, Hardy, John, Vrièze, Fabienne and Glaser, Anna 2009. Further analysis of previously implicated linkage regions for Alzheimer's disease in affected relative pairs. BMC Medical Genetics 10 , pp. 1-6. 10.1186/1471-2350-10-122

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Abstract

Background Genome-wide linkage studies for Alzheimer's disease have implicated several chromosomal regions as potential loci for susceptibility genes. Methods In the present study, we have combined a selection of affected relative pairs (ARPs) from the UK and the USA included in a previous linkage study by Myers et al. (Am J Med Genet, 2002), with ARPs from Sweden and Washington University. In this total sample collection of 397 ARPs, we have analyzed linkage to chromosomes 1, 9, 10, 12, 19 and 21, implicated in the previous scan. Results The analysis revealed that linkage to chromosome 19q13 close to the APOE locus increased considerably as compared to the earlier scan. However, linkage to chromosome 10q21, which provided the strongest linkage in the previous scan could not be detected. Conclusion The present investigation provides yet further evidence that 19q13 is the only chromosomal region consistently linked to Alzheimer's disease.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI) Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > R Medicine (General)
Publisher:	BioMed Central
ISSN:	1471-2350
Date of First Compliant Deposit:	30 March 2016
Last Modified:	05 May 2023 16:05
URI:	https://orca.cardiff.ac.uk/id/eprint/28493

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