Tight junctions in cancer metastasis

Martin, Tracey Amanda ORCID: https://orcid.org/0000-0003-2690-4908, Mason, Malcolm David ORCID: https://orcid.org/0000-0003-1505-2869 and Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111 2011. Tight junctions in cancer metastasis. Frontiers in Bioscience 16 (3) , pp. 898-936. 10.2741/3726

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Abstract

Tight Junctions (TJ) are well known to function as a control for the paracellular diffusion of ions and certain molecules, it has however, become evident that the TJ has a vital role in maintaining cell to cell integrity. Loss of cohesion of the TJ structure can lead to invasion and ultimately to the metastasis of cancer cells. This review will discuss how modulation of expression of TJ molecules results in key changes in TJ barrier function leading to the progression of cancer and progression of metastasis.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Publisher:	Frontiers in Bioscence
ISSN:	1093-9946
Last Modified:	06 Nov 2022 14:10
URI:	https://orca.cardiff.ac.uk/id/eprint/28847

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