Retrieval-mediated learning involving episodes requires synaptic plasticity in the hippocampus

Iordanova, Mihaela D., Good, Mark Andrew ORCID: https://orcid.org/0000-0002-1824-1203 and Honey, Robert Colin ORCID: https://orcid.org/0000-0001-6870-1880 2011. Retrieval-mediated learning involving episodes requires synaptic plasticity in the hippocampus. The Journal of Neuroscience 31 (19) , pp. 7156-7162. 10.1523/JNEUROSCI.0295-11.2011

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Abstract

A novel association can form between two memories even when the events to which they correspond are not physically present. For example, once an integrated memory has formed that binds the (when, where, and what) components of an event together, this memory can be triggered by one of its components, and updated with coincident information in the environment. The neural basis of this form of retrieval-mediated learning is unknown. Here, we show, for the first time, that NMDA receptors in the rat hippocampus are required for retrieval-mediated learning involving episodes, but not for the expression of such learning or for retrieval-mediated learning involving simple associations between the components of episodes. These findings provide a novel insight into learning processes that serve the desirable function of integrating stored information with new information, but whose operation might also provide a substrate for some of the cognitive symptoms of schizophrenia and Alzheimer's disease.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Society for Neuroscience
ISSN:	0270-6474
Date of First Compliant Deposit:	30 March 2016
Last Modified:	12 May 2023 16:29
URI:	https://orca.cardiff.ac.uk/id/eprint/30096

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