Very long chain fatty acid levels in patients diagnosed with multiple sclerosis

Wilkins, Alastair, Ingram, Gillian, Brown, Anny, Jardine, Philip, Steward, Colin G, Robertson, Neil ORCID: https://orcid.org/0000-0002-5409-4909 and Scolding, Neil J 2009. Very long chain fatty acid levels in patients diagnosed with multiple sclerosis. Multiple Sclerosis Journal 15 (12) , pp. 1525-1527. 10.1177/1352458509351731

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Abstract

In clinical practice it is not uncommon for patients with adrenomyeloneuropathy or female carriers of adrenoleucodystrophy to have a presenting history and examination compatible with multiple sclerosis. This suggests that there may be an under-diagnosis of adrenoleucodystrophy and its variants in the multiple sclerosis population. We measured levels of very long chain fatty acids, which are typically elevated in the plasma of patients with adrenoleucodystrophy, in a large cohort of patients diagnosed clinically with multiple sclerosis. We tested serum samples from patients with either a first degree relative with multiple sclerosis or those with a primary progressive phenotype. No elevations in very long chain fatty acids were found in the cohort. This study suggests that the number of cases of adrenomyeloneuropathy or adrenoleucodystrophy amongst patients diagnosed clinically with multiple sclerosis is likely to be extremely low. This has important diagnostic implications.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine
Uncontrolled Keywords:	Multiple sclerosis ; Genetics
Publisher:	Sage
ISSN:	1352-4585
Last Modified:	20 Oct 2022 08:57
URI:	https://orca.cardiff.ac.uk/id/eprint/30165

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