Hepatocyte growth factor regulation: an integral part of why wounds become chronic

Conway, Kevin P., Ruge, Fiona, Price, Patricia Elaine, Harding, Keith Gordon and Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111 2007. Hepatocyte growth factor regulation: an integral part of why wounds become chronic. Wound Repair and Regeneration 15 (5) , pp. 683-692. 10.1111/j.1524-475X.2007.00296.x

Full text not available from this repository.

Abstract

Hepatocyte growth factor (HGF) is a cytokine known to play multiple roles during the various stages of wound healing. This study addresses the ongoing key questions regarding the role of HGF in wound healing, namely: are HGF and its regulators expressed differently in chronic and acute wounds? Biopsies from normal skin (n=10), acute (n=10), and chronic wounds (n=17) were analyzed by immunohistochemistry, reverse transcriptase polymerase chain reaction (RT-PCR), and quantitative real-time RT-PCR for the presence of HGF, its receptor cMet, its activators and its inhibitors. Immunohistochemical staining for HGF, HGF activators, and HGF inhibitors was similar, with expression being greater in chronic wound dermis compared with acute wound dermis. While expression of cMet in chronic wound dermis was less than in the acute wound dermis. PCR quantification of these proteins showed similar trends although the differences did not reach statistical significance. The results of this study provide important data confirming the role of HGF in wound healing. In addition, we have demonstrated the aberrant expression of the HGF receptor cMet and activation inhibitors (HAI-1 and HAI-2) in chronic wounds. This aberrant expression may have a value in predicting the process of healing and nonhealing wounds and constitute important targets of future therapies.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Healthcare Sciences
Subjects:	R Medicine > R Medicine (General)
Publisher:	Elsevier
ISSN:	1067-1927
Last Modified:	20 Oct 2022 09:05
URI:	https://orca.cardiff.ac.uk/id/eprint/30630

Citation Data

Cited 33 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item