Evidence for endogenous opioid release in the amygdala during positive emotion

Koepp, M., Hammers, A., Lawrence, Andrew David ORCID: https://orcid.org/0000-0001-6705-2110, Asselin, M., Grasby, P. and Bench, C. 2009. Evidence for endogenous opioid release in the amygdala during positive emotion. NeuroImage 44 (1) , pp. 252-256. 10.1016/j.neuroimage.2008.08.032

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Abstract

Endogenous opioid release has been linked to relief from aversive emotional memories, thereby promoting a euphoric state and subsequent interactions towards social stimuli resulting in the formation of social preferences. However, this theory remains controversial. Using positron emission tomography and [11C]diprenorphine (DPN) in healthy volunteers, we found significantly reduced DPN binding to opioid receptor in the hippocampus during positive mood induction compared to neutral mood. Furthermore, the magnitude of positive mood change correlated negatively with DPN binding in the amygdala bilaterally. Our finding of reduced DPN binding is consistent with increased release of endogenous opioids, providing direct evidence that localised release of endogenous opioids is involved in the regulation of positive emotion in humans.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	Opioid peptides; Emotions; PET; Amygdala; Mood induction
Publisher:	Elsevier
ISSN:	1053-8119
Last Modified:	20 Oct 2022 09:07
URI:	https://orca.cardiff.ac.uk/id/eprint/30730

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