Cholinergic transmission is essential for perirhinal cortical plasticity and recognition memory

Warburton, Elizabeth Clea, Koder, Timothy, Cho, Kwangwook, Massey, Peter V., Duguid, Gail, Barker, Gareth R.I., Aggleton, John Patrick ORCID: https://orcid.org/0000-0002-5573-1308, Bashir, Zafar I. and Brown, Malcolm W. 2003. Cholinergic transmission is essential for perirhinal cortical plasticity and recognition memory. Neuron 38 (6) , pp. 987-996. 10.1016/S0896-6273(03)00358-1

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Abstract

We establish the importance of cholinergic neurotransmission to both recognition memory and plasticity within the perirhinal cortex of the temporal lobe. The muscarinic receptor antagonist scopolamine impaired the preferential exploration of novel over familiar objects, disrupted the normal reduced activation of perirhinal neurones to familiar compared to novel pictures, and blocked production of long-term depression (LTD) but not long-term potentiation (LTP) of synaptic transmission in perirhinal slices. The consistency of these effects across the behavioral, systems, and cellular levels of analysis provides strong evidence for the involvement of cholinergic mechanisms in synaptic plastic processes within perirhinal cortex that are necessary for recognition memory.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Cell Press
ISSN:	0896-6273
Last Modified:	17 Oct 2022 09:27
URI:	https://orca.cardiff.ac.uk/id/eprint/3255

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