Context- but not familiarity-dependent forms of object recognition are impaired following excitotoxic hippocampal lesions in rats

Good, Mark Andrew ORCID: https://orcid.org/0000-0002-1824-1203, Barnes, Philip Andrew, Staal, Victoria Ann, McGregor, Anthony and Honey, Robert Colin ORCID: https://orcid.org/0000-0001-6870-1880 2007. Context- but not familiarity-dependent forms of object recognition are impaired following excitotoxic hippocampal lesions in rats. Behavioral Neuroscience 121 (1) , pp. 218-223. 10.1037/0735-7044.121.1.218

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Abstract

Dual-process models of recognition memory in animals propose that recognition memory is supported by two independent processes that reflect the operation of distinct brain structures: a familiarity process that operates independently of the hippocampus and a context-dependent (episodic) memory process that is dependent on the hippocampus. A novel variant of an object recognition procedure was used to examine this proposal. Healthy rats showed a preference for exploring a novel object rather than a familiar object: a familiarity-dependent recognition effect. They also showed a preference for exploring a familiar object that was presented in a different spatiotemporal context rather than a familiar object that was presented either in a different spatial or temporal context: a context-dependent form of recognition that is sensitive to 'what' object has been presented 'where' and 'when.' Rats with excitotoxic hippocampal lesions showed the familiarity-dependent but not the context-dependent form of recognition. The results provide support for dual-process theories of recognition memory.

Item Type:	Article
Status:	Published
Schools:	Psychology
Publisher:	American Psychological Association
ISSN:	1939-0084
Last Modified:	20 Oct 2022 09:46
URI:	https://orca.cardiff.ac.uk/id/eprint/33042

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