Impaired Pavlovian cued fear conditioning in Tg2576 mice expressing a human mutant amyloid precursor protein gene

Barnes, Philip and Good, Mark Andrew ORCID: https://orcid.org/0000-0002-1824-1203 2005. Impaired Pavlovian cued fear conditioning in Tg2576 mice expressing a human mutant amyloid precursor protein gene. Behavioural Brain Research 157 (1) , pp. 107-117. 10.1016/j.bbr.2004.06.014

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Abstract

The processing of emotional and/or fear-related events is abnormal in patients with Alzheimer’s disease. AD is accompanied by a number of neuropathological features, one of which is the deposition of amyloid plaques. The main aim of the present study was to examine the effects of a human amyloid precursor protein mutation on both the acquisition and expression of fear conditioning in Tg2576 mice. Sixteen-month-old, but not 4-month-old, transgenic mice showed aberrations in post-shock freezing during training. In a retention test carried out 24 h after training, Tg2576 mice showed comparable levels of conditioned fear elicited by contextual cues. However, freezing elicited by a tone conditioned stimulus was impaired in 16-month-old but not 4-month-old Tg2576 mice. The results are discussed with reference to the role of cue competition (overshadowing) in revealing fear conditioning deficits in Tg2576 mice.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	Alzheimer’s disease; Fear conditioning; Tg2576; Context; Cued; Amyloid
Publisher:	Elsevier
ISSN:	0166-4328
Last Modified:	20 Oct 2022 09:48
URI:	https://orca.cardiff.ac.uk/id/eprint/33161

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