Testing the importance of the caudal retrosplenial cortex for spatial memory in rats

Vann, Seralynne Denise ORCID: https://orcid.org/0000-0002-6709-8773, Wilton, L. A. K., Muir, Janice L. and Aggleton, John Patrick ORCID: https://orcid.org/0000-0002-5573-1308 2003. Testing the importance of the caudal retrosplenial cortex for spatial memory in rats. Behavioural Brain Research 140 (1-2) , pp. 107-118. 10.1016/S0166-4328(02)00274-7

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Abstract

Although there is evidence to suggest that the retrosplenial cortex is involved in spatial learning and memory, many lesion studies have left the more caudal part of this region intact so leaving its role untested. In the first experiment, rats with neurotoxic lesions of the caudal half of the retrosplenial cortex (RspC1) were tested on a reference memory task in the water-maze. The RspC1 animals were impaired on initial acquisition although they performed normally on a subsequent probe test. The second experiment looked at working memory in the radial-arm maze and water-maze. Animals with caudal retrosplenial lesions (RspC2) were unimpaired on the acquisition stage of the radial-arm maze task but were impaired when the task involved maze rotation to control for the possible use of intramaze cues. The RspC2 animals also took longer to learn the platform position on a delayed matching-to-place task in the water-maze. These results show a subtle impairment in spatial memory performance that is not as severe as that seen when more complete lesions of the retrosplenial cortex are made.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	Cingulate cortex; Cingulum; Retrosplenial cortex; Hippocampus; Spatial memory; Water-maze
Publisher:	Elsevier
ISSN:	0166-4328
Last Modified:	07 Nov 2023 11:17
URI:	https://orca.cardiff.ac.uk/id/eprint/33246

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