Evidence for the presence of neurokinin-1 receptors on dorsal horn spinocerebellar tract cells in the rat

McGonigle, David ORCID: https://orcid.org/0000-0001-9595-6352, Maxwell, D. J., Shehab, S. A. S. and Kerr, R. 1996. Evidence for the presence of neurokinin-1 receptors on dorsal horn spinocerebellar tract cells in the rat. Brain Research 742 (1-2) , pp. 1-9. 10.1016/S0006-8993(96)00942-0

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Abstract

Dorsal horn spinocerebellar tract cells of adult rats were labelled by retrograde axonal transport with the B subunit of cholera toxin. Sections were prepared from lumbar and thoracic spinal segments and incubated with antisera which specifically recognise neurokinin-1 receptor protein and substance P. Labelled cells and immunoreactivity for the receptor and substance P were identified by using three different fluorophores and the relationships between them were assessed in single optical sections with three-colour confocal laser scanning microscopy. Forty-eight cells were examined and 23 of them displayed immunoreactivity for the receptor. Many substance P-immunoreactive profiles were present in lamina V and some formed contacts with spinocerebellar tract cells possessing neurokinin-1 receptor immunoreactivity. The evidence suggests that substance P may influence the activity of a subpopulation of dorsal horn spinocerebellar tract cells by acting through neurokinin-1 receptors.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	Tachykinin receptor; Substance P; Immunofluorescence; Confocal microscopy; Proprioception
Publisher:	Elsevier
ISSN:	0006-8993
Last Modified:	20 Oct 2022 09:50
URI:	https://orca.cardiff.ac.uk/id/eprint/33262

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