Imaging how attention modulates pain in humans using functional MRI

Bantick, S. J., Wise, Richard Geoffrey ORCID: https://orcid.org/0000-0003-1700-2144, Ploghaus, A., Clare, S., Smith, S. M. and Tracey, I. 2002. Imaging how attention modulates pain in humans using functional MRI. Brain 125 (2) , pp. 310-319. 10.1093/brain/awf022

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Abstract

Current clinical and experimental literature strongly supports the phenomenon of reduced pain perception whilst attention is distracted away from noxious stimuli. This study used functional MRI to elucidate the underlying neural systems and mechanisms involved. An analogue of the Stroop task, the counting Stroop, was used as a cognitive distraction task whilst subjects received intermittent painful thermal stimuli. Pain intensity scores were significantly reduced when subjects took part in the more cognitively demanding interference task of the counting Stroop than in the less demanding neutral task. When subjects were distracted during painful stimulation, brain areas associated with the affective division of the anterior cingulate cortex (ACC) and orbitofrontal regions showed increased activation. In contrast, many areas of the pain matrix (i.e. thalamus, insula, cognitive division of the ACC) displayed reduced activation, supporting the behavioural results of reduced pain perception.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	functional MRI; pain; counting stroop; attention; cingulate
Publisher:	Oxford University Press
ISSN:	1460-2156
Last Modified:	20 Oct 2022 09:55
URI:	https://orca.cardiff.ac.uk/id/eprint/33521

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