Embryo freezing for preventing ovarian hyperstimulation syndrome: a Cochrane review

D'Angelo, Arianna and Amso, Nazar Najib ORCID: https://orcid.org/0000-0002-8646-6623 2002. Embryo freezing for preventing ovarian hyperstimulation syndrome: a Cochrane review. Human Reproduction 17 (11) , pp. 2787-2794. 10.1093/humrep/17.11.2787

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Abstract

BACKGROUND: Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic condition resulting from an excessive ovarian response to superovulation medication. The objective of this review was to evaluate the effectiveness of cryopreservation (embryo freezing) when compared with human i.v. albumin infusion and with fresh embryo transfer for the prevention of OHSS. METHODS: This was based on a Cochrane Review. Randomized controlled trials in which either human i.v. albumin or cryopreservation of all embryos was used as a therapeutic approach to OHSS were included. The participants were women down-regulated by GnRH agonist, undergoing superovulation in IVF/ICSI cycles. The interventions compared were cryopreservation versus i.v. human albumin administration and elective cryopreservation of all embryos versus fresh embryo transfer. The primary outcomes were: incidence of moderate and severe OHSS versus nil/mild OHSS, and clinical pregnancies/woman. Statistical analysis was performed in accordance with the Cochrane Menstrual Disorders and Subfertility Group guidelines. RESULTS: Seventeen studies were identified, two of which met our inclusion criteria. One study was included where cryopreservation was compared with i.v. human albumin administration and another where elective cryopreservation of all embryos was compared with fresh embryo transfer. In both interventions no difference was found in all the outcomes examined between the two groups. CONCLUSIONS: This review has shown that there is insufficient evidence to support routine cryopreservation and insufficient evidence for the relative merits of i.v. albumin versus cryopreservation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General) R Medicine > RG Gynecology and obstetrics
Uncontrolled Keywords:	elective cryopreservation ;i.v. albumin ;ovarian hyperstimulation syndrome ;randomized controlled trials ;systematic review
Publisher:	Oxford University Press
ISSN:	0268-1161
Last Modified:	07 Nov 2022 09:15
URI:	https://orca.cardiff.ac.uk/id/eprint/33967

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