Serotonergic functioning in children with oppositional defiant disorder: a sumatriptan challenge study

Snoek, Heddeke, Van Goozen, Stephanie Helena Maria ORCID: https://orcid.org/0000-0002-5983-4734, Matthys, Walter, Sigling, Hein O., Koppeschaar, Hans P. F., Westernberg, Herman G. M. and Van Engeland, Herman 2002. Serotonergic functioning in children with oppositional defiant disorder: a sumatriptan challenge study. Biological psychiatry 51 (4) , pp. 319-325. 10.1016/S0006-3223(01)01230-6

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Abstract

Background: Several studies support the notion that disturbances in the central serotonergic function are related to impulsive aggression. There is recent evidence from studies on 5-HT1B knock-out mice that this specific receptor is involved in impulsive aggressive behavior. The aim of the present study was to investigate 5-HT1B/1D receptor functioning in normal intelligent hospitalized children with oppositional defiant disorder (ODD). Methods: The growth hormone (GH) response to a challenge with the 5-HT1B/1D agonist sumatriptan was examined in 20 children with an ODD, of whom 13 had an attention-deficit/hyperactivity disorder comorbidity, and 15 normal control subjects (NC). Blood samples for growth hormone were collected repeatedly between 8:30 and 12:00 am. Sumatriptan was administered at 10 am. The effect of stress due to this procedure was assessed by measuring salivary cortisol. Results: The GH response was significantly stronger in the children with ODD. After sumatriptan injection NC children showed a significant increase in cortisol; no such pattern was present in the ODD group. Conclusions: The results suggest that the postsynaptic 5-HT1B/1D receptor is functionally more sensitive in children with ODD.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Psychology Research Institutes & Centres > Neuroscience and Mental Health Research Institute (NMHII)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	Serotonin; aggression; sumatriptan; child psychiatry; 5-HT1B/1D receptors
Publisher:	Elsevier
ISSN:	0006-3223
Last Modified:	17 Oct 2022 09:31
URI:	https://orca.cardiff.ac.uk/id/eprint/3413

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