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T-cell responses during Trypanosoma brucei infections in mice deficient in inducible nitric oxide synthase

Millar, Amanda E., Sternberg, Jerry, McSharry, Charlie, Wei, Xiao-Qing, Liew, Foo Y. and Turner, C. Michael R. 1999. T-cell responses during Trypanosoma brucei infections in mice deficient in inducible nitric oxide synthase. Infection and Immunity 67 (7) , pp. 3334-3338.

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We have investigated the possibility that nitric oxide (NO) synthesis may affect the course of a trypanosome infection via T-cell responses using mice deficient in inducible NO synthase (iNOS). Parasitemia levels increased at the same rate in both iNOS-deficient homozygous and control heterozygous mice, and peak parasitemia values were the same in both groups. However, the heterozygous mice maintained higher parasitemia levels after the peak of an infection than the homozygous mice due to a decrease in the rate of clearance of parasites. In iNOS-deficient mice there was an increase in the numbers of total CD41 cells and activated (interleukin- 2 receptor-expressing) CD41 cells in infected mice compared with the numbers in uninfected mice. Spleen cells from infected iNOS-deficient mice displayed increased proliferative responses and gamma interferon secretion when stimulated in vitro than those of control mice. These data suggest that NO production depresses T-helper 1-like responses generated during Trypanosoma brucei infections, thus promoting the survival of the parasite.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Dentistry
Subjects: R Medicine > R Medicine (General)
Additional Information: Pdf uploaded in accordance with publisher's policy at (accessed 24/02/2014)
Publisher: American Society for Microbiology
ISSN: 0019-9567
Date of First Compliant Deposit: 30 March 2016
Last Modified: 04 Jun 2017 04:16

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