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Investigation of role of nitric oxide in protection from Bordetella pertussis respiratory challenge

Canthaboo, C., Xing, D., Wei, Xiao-Qing and Corbel, M. J. 2002. Investigation of role of nitric oxide in protection from Bordetella pertussis respiratory challenge. Infection and Immunity 70 (2) , pp. 679-684. 10.1128/IAI.70.2.679-684.2002

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The mechanism whereby whole-cell pertussis vaccines (WCV) confer protection against Bordetella pertussis is still not fully understood. We have previously reported that macrophage activation produced by vaccination with WCV is associated with induction of NO synthesis by macrophages in response to in vitro stimulation with B. pertussis antigens. To determine whether NO production is an effector of protection or simply a marker of activation, the susceptibility of inducible nitric oxide synthase (type II, iNOS) knockout mice to infection with B. pertussis was examined. We showed that iNOS knockout mice were more susceptible to B. pertussis respiratory challenge than wild-type mice. iNOS-deficient mice also developed a less effective protective response than wild-type mice after the same immunization with WCV. This suggests that NO plays an important role in effecting protection against B. pertussis challenge.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Dentistry
Subjects: Q Science > QR Microbiology > QR180 Immunology
Additional Information: Pdf uploaded in accordance with publisher's policy at (accessed 24/02/2014)
Publisher: American Society for Microbiology
ISSN: 0019-9567
Date of First Compliant Deposit: 30 March 2016
Last Modified: 04 Jun 2017 04:16

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