Cytomics and cellular informatics - coping with asymmetry and heterogeneity in biological systems

Smith, Paul James, Khan, Imtiaz Ali and Errington, Rachel Jane ORCID: https://orcid.org/0000-0002-8016-4376 2009. Cytomics and cellular informatics - coping with asymmetry and heterogeneity in biological systems. Drug Discovery Today 14 (5-6) , pp. 271-277. 10.1016/j.drudis.2008.11.012

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Abstract

Cytomics has a practical role to play in drug discovery within the immediate limitations of cell-based analyses. A more elusive goal is the clarification of the complexity of a dynamic cellular response to a drug through mathematical modelling. The common aim for drug discovery and cytomics is to bridge the molecular–cellularsystems gap. The strategic challenges faced include: suitable preclinical biological models, cytometric platforms that resolve cellular or behavioural identity, analysis and visualization tools that act as integrating principles, consensus on standards and, finally, the implementation of informatics to serve the demands of decision making. Advances in all these key areas will help to address the need to identify and evaluate the origins of asymmetry and heterogeneity in cellularsystems and thus reveal new opportunities for therapeutic targeting.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	Q Science > QH Natural history > QH301 Biology Q Science > QH Natural history > QH426 Genetics R Medicine > R Medicine (General)
Publisher:	Elsevier
ISSN:	1359-6446
Last Modified:	21 Oct 2022 09:37
URI:	https://orca.cardiff.ac.uk/id/eprint/37107

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