Magnetic field tomography of coherent thalamocortical 40-Hz oscillations in humans

Ribary, U., Ioannides, A. A., Singh, Krish Devi ORCID: https://orcid.org/0000-0002-3094-2475, Hasson, R., Bolton, J. P. R., Lado, F., Mogilner, A. and Llinás, R. 1991. Magnetic field tomography of coherent thalamocortical 40-Hz oscillations in humans. Proceedings of the National Academy of Sciences of the United States of America 88 (24) , pp. 11037-11041.

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Abstract

This paper introduces the use of magnetic field tomography (MFT), a noninvasive technique based on distributed source analysis of magnetoencephalography data, which makes possible the three-dimensional reconstruction of dynamic brain activity in humans. MFT has a temporal resolution better than 1 msec and a spatial accuracy of 2-5 mm at the cortical level, which deteriorates to 1-3 cm at depths of 6 cm or more. MFT is used here to visualize the origin of a spatiotemporally organized pattern of coherent 40-Hz electrical activity. This coherence, initially observed during auditory input, was proposed to be generated by recurrent corticothalamic oscillation. In support of this hypothesis, we illustrate well-defined 40-Hz coherence between cortical-subcortical sites with a time shift that is consistent with thalamocortical conduction times. Studies on Alzheimer patients indicate that, while a similar activity pattern is present, the cortical component is reduced in these subjects.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	National Academy of Sciences
ISSN:	0027-8424
Last Modified:	21 Oct 2022 09:53
URI:	https://orca.cardiff.ac.uk/id/eprint/38204

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