Polymerase chain reaction aids in the diagnosis of an unusual case of Aspergillus niger endocarditis in a patient with acute myeloid leukaemia

McCracken, D., Barnes, Rosemary Ann, Poynton, Christopher H., White, P. L., Isik, N. and Cook, D. 2003. Polymerase chain reaction aids in the diagnosis of an unusual case of Aspergillus niger endocarditis in a patient with acute myeloid leukaemia. Journal of Infection 47 (4) , pp. 344-347. 10.1016/S0163-4453(03)00084-7

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Abstract

Endocarditis secondary to Aspergillusniger has not been described in a leukaemic patient. We describe acase of A. nigerendocarditis in apatient with acute myeloid leukaemia and refractory fever. The microbiological cause of his endocarditis was initially misdiagnosed because he fulfilled the Duke criteria for enterococcal endocarditis. Apolymerasechainreaction test utilizing pan-fungal primers detected a product from an Aspergillus sp. The DNA was subsequently sequenced and was found to have 100% homology with A. niger. A postmortem revealed fungal endocarditis secondary to disseminated aspergillosis, without evidence of bacterial endocarditis. The patient was found to have a lung aspergilloma that was possibly occupationally acquired, and may have been long standing.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords:	Aspergillusniger; Endocarditis; Leukaemia
Publisher:	Elsevier
ISSN:	0163-4453
Last Modified:	04 Jun 2017 04:26
URI:	https://orca.cardiff.ac.uk/id/eprint/39028

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