Depression in adolescence

Thapar, Anita ORCID: https://orcid.org/0000-0002-3689-737X, Collishaw, Stephan ORCID: https://orcid.org/0000-0002-4296-820X, Pine, Daniel S. and Thapar, Ajay Kumar ORCID: https://orcid.org/0000-0002-4589-8833 2012. Depression in adolescence. The Lancet 379 (9820) , pp. 1056-1067. 10.1016/S0140-6736(11)60871-4

Full text not available from this repository.

Abstract

Unipolar depressive disorder in adolescence is common worldwide but often unrecognised. The incidence, notably in girls, rises sharply after puberty and, by the end of adolescence, the 1 year prevalence rate exceeds 4%. The burden is highest in low-income and middle-income countries. Depression is associated with substantial present and future morbidity, and heightens suicide risk. The strongest risk factors for depression in adolescents are a family history of depression and exposure to psychosocial stress. Inherited risks, developmental factors, sex hormones, and psychosocial adversity interact to increase risk through hormonal factors and associated perturbed neural pathways. Although many similarities between depression in adolescence and depression in adulthood exist, in adolescents the use of antidepressants is of concern and opinions about clinical management are divided. Effective treatments are available, but choices are dependent on depression severity and available resources. Prevention strategies targeted at high-risk groups are promising.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Elsevier
ISSN:	0140-6736
Last Modified:	21 Oct 2022 10:46
URI:	https://orca.cardiff.ac.uk/id/eprint/41314

Citation Data

Cited 1381 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item