Barker, S. A., Cottrell, S. P., Giblin, Sean  ORCID: https://orcid.org/0000-0003-1876-8619 and Jayasooriya, U. A.
2006.
Preliminary μSR studies on the incorporation of steroidal drug molecules into liposomes.
Physica B: Condensed Matter
374
, pp. 332-335.
10.1016/j.physb.2005.11.089
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Abstract
Muon spin relaxation of two liposome samples consisting of 100% DPPC (dipalmitoylphosphatidylcholine) and 50:50 mole% DPPC:Cholesterol at a final lipid concentration of 100 mg/mL are compared. The observation of a significant loss in the muonium fraction from 11% to 6% when cholesterol is present is compatible with radical formation in the second sample. Also reported are measurements on pure solid cholesterol where a clear T1 minimum at ca 100 K, corresponding to a dynamic process with activation energy of ca. 1.89 kJ mol−1 and an attempt frequency of 5.89×1010 s−1, is observed. An estimate of a hyperfine interaction of 255.4 MHz for this radical predicts a ΔM=1 ALC transition at 0.94 T.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Physics and Astronomy |
| Subjects: | Q Science > QC Physics |
| Uncontrolled Keywords: | Drug delivery; Liposomes; Steroids; Spin resonance |
| Additional Information: | Proceedings of the Tenth International Conference on Muon Spin Rotation, Relaxation and Resonance |
| Publisher: | Elsevier |
| ISSN: | 0921-4526 |
| Last Modified: | 21 Oct 2022 10:50 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/41492 |
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