Preliminary μSR studies on the incorporation of steroidal drug molecules into liposomes

Barker, S. A., Cottrell, S. P., Giblin, Sean ORCID: https://orcid.org/0000-0003-1876-8619 and Jayasooriya, U. A. 2006. Preliminary μSR studies on the incorporation of steroidal drug molecules into liposomes. Physica B: Condensed Matter 374 , pp. 332-335. 10.1016/j.physb.2005.11.089

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Abstract

Muon spin relaxation of two liposome samples consisting of 100% DPPC (dipalmitoylphosphatidylcholine) and 50:50 mole% DPPC:Cholesterol at a final lipid concentration of 100 mg/mL are compared. The observation of a significant loss in the muonium fraction from 11% to 6% when cholesterol is present is compatible with radical formation in the second sample. Also reported are measurements on pure solid cholesterol where a clear T1 minimum at ca 100 K, corresponding to a dynamic process with activation energy of ca. 1.89 kJ mol−1 and an attempt frequency of 5.89×1010 s−1, is observed. An estimate of a hyperfine interaction of 255.4 MHz for this radical predicts a ΔM=1 ALC transition at 0.94 T.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Physics and Astronomy
Subjects:	Q Science > QC Physics
Uncontrolled Keywords:	Drug delivery; Liposomes; Steroids; Spin resonance
Additional Information:	Proceedings of the Tenth International Conference on Muon Spin Rotation, Relaxation and Resonance
Publisher:	Elsevier
ISSN:	0921-4526
Last Modified:	21 Oct 2022 10:50
URI:	https://orca.cardiff.ac.uk/id/eprint/41492

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