blaNDM-1 is a chimera likely constructed in acinetobacter baumannii

Toleman, Mark Alexander Howard ORCID: https://orcid.org/0000-0002-9497-0512, Spencer, J., Jones, Lim Stephen and Walsh, Timothy Rutland ORCID: https://orcid.org/0000-0003-4315-4096 2012. blaNDM-1 is a chimera likely constructed in acinetobacter baumannii. Antimicrobial Agents and Chemotherapy 56 (5) , pp. 2773-2776. 10.1128/AAC.06297-11

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Abstract

Alignment of DNA sequences found upstream of aphA6 and all blaNDM-1 genes displays 100% identity. This identity continues 19 bp into the blaNDM-1 gene such that the first 6 amino acids of aphA6 and blaNDM-1 are the same. Furthermore, the percent GC content (GC%) of aphA6 is considerably lower than that of blaNDM-1 and the GC% within the blaNDM-1 structural gene changes dramatically after the first 19 bp. This is unequivocal evidence that blaNDM-1 is a chimera.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Systems Immunity Research Institute (SIURI)
Subjects:	Q Science > QR Microbiology R Medicine > R Medicine (General)
Additional Information:	Pdf uploaded in accordance with publisher's policy at http://www.sherpa.ac.uk/romeo/issn/0066-4804/ (accessed 24/02/2014)
Publisher:	American Society for Microbiology
ISSN:	0066-4804
Date of First Compliant Deposit:	30 March 2016
Last Modified:	18 May 2023 06:23
URI:	https://orca.cardiff.ac.uk/id/eprint/42337

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