Molecular impact of bone morphogenetic protein 7, on lung cancer cells and its clinical significance

Liu, Yinan, Chen, Jinfeng, Yang, Yue, Zhang, Lijian and Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111 2012. Molecular impact of bone morphogenetic protein 7, on lung cancer cells and its clinical significance. International Journal of Molecular Medicine 29 (6) , pp. 1016-1024. 10.3892/ijmm.2012.948

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Abstract

The aim of this study was to investigate the expression of bone morphogenetic protein 7 (BMP7), in human pulmonary cancer tissues/cells and to evaluate the cellular impact of bone morphogenetic proteins on pulmonary cancer cells. BMP7 expression was determined in human lung cancer cell lines. The invasiveness and growth of cells transfected with BMP7, in vitro, were evaluated using the in vitro invasion assay and in vitro tumour models. Cellular migration was analysed using wounding assays. BMP7-positive tumours correlated with the absence of bone metastasis (P=0.040). In this analysis, we identified that 4 of 4 small cell lung cancer (SCLC) tissue specimens had no BMP7 expression, which illustrated that BMP7 may have no role in SCLC. BMP7 expression was not correlated with the overall survival time in lung cancer patients. Downregulation of BMP7 expression significantly inhibited the invasiveness of SPC-A1 cells (P<0.001) and forced-expression of BMP7 dramatically increased the motility of A549 cells. Overexpression of BMP7 in A549 cells and its knockdown in SPC-A1 cells did not significantly alter proliferation compared with the control cells (P>0.5 respectively). In conclusion, we have demonstrated that BMP7 has an important role in controlling lung cancer cell motility and invasiveness, without affecting the growth process, cell proliferation and cell apoptosis. A higher BMP7 expression may be an indicator for bone metastasis. The therapeutic role of BMP7 warrants further investigation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Additional Information:	Pdf uploaded in accordance with publisher's policy at http://www.sherpa.ac.uk/romeo/issn/1107-3756/ (accessed 24/02/2014).
Publisher:	Spandidos Publications
ISSN:	1107-3756
Date of First Compliant Deposit:	30 March 2016
Last Modified:	16 May 2023 18:00
URI:	https://orca.cardiff.ac.uk/id/eprint/43629

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