Major, Guy  ORCID: https://orcid.org/0000-0002-4193-6601, Larkurn, Matthew and Schiller, Jackie
2013.
Active properties of neocortical pyramidal neuron dendrites.
Annual Review of Neuroscience
36
, pp. 1-24.
10.1146/annurev-neuro-062111-150343
|
Abstract
Dendrites are the main recipients of synaptic inputs and are important sites determining neurons input-output functions. This review focuses on thin neocortical dendrites, which receive the vast majority of synaptic inputs in cortex but also have specialized electrogenic properties. We present a simplified working model biophysical scheme of pyramidal neurons that attempts to capture the essence of their dendritic function, including the ability to behave under plausible conditions as dynamic computational sub-units. We emphasize the electrogenic capabilities of NMDA receptors (NMDA-Rs), as these transmitter-gated channels seem to provide the major nonlinear depolarizing drive in thin dendrites, even allowing full-blown NMDA spikes. We show how apparent discrepancies in experimental findings can be reconciled and discuss the current status of dendritic spikes in vivo; a dominant NMDA-R contribution would mean the input-output relations of thin dendrites are dynamically set by network activity, and cannot be fully predicted by purely reductionist approaches.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Biosciences |
| Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| Publisher: | Annual Reviews |
| ISSN: | 0147-006X |
| Last Modified: | 24 Oct 2022 11:17 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/47561 |
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