Evaluation of multimodal imaging in carriers of X-linked retinitis pigmentosa

Acton, Jennifer H. ORCID: https://orcid.org/0000-0002-0347-7651, Greenberg, Jonathan P., Greenstein, Vivienne C., Marsiglia, Marcela, Tabacaru, Mirela, Theodore Smith, R. and Tsang, Stephen H. 2013. Evaluation of multimodal imaging in carriers of X-linked retinitis pigmentosa. Experimental Eye Research 113 , pp. 41-48. 10.1016/j.exer.2013.05.003

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Abstract

The aim of this study was to investigate visualization of the tapetal-like reflex using current imaging modalities and evaluate SD-OCT changes in known carriers of X-linked retinitis pigmentosa (XLRP); the objective being the development of an optimal protocol for clinicians to identify carriers. Ten XLRP carriers (19 eyes) were examined using color fundus photography, 488 nm reflectance (488-R), near-infrared reflectance (NIR-R), autofluorescence (AF) and spectral domain optical coherence tomography (SD-OCT) imaging (Spectralis SLO-OCT, Heidelberg). Horizontal line scans through the fovea were acquired in all subjects and in a group of 10 age-similar controls. Peripheral SD-OCT scans (extending to 27.5° eccentricity) were also acquired in both eyes of 7 carriers. MP-1 microperimetery (10-2 pattern; Nidek) was performed in one eye of each carrier. For the XLRP carriers, a tapetal reflex was observed with all imaging modalities in 8 of 19 eyes. It had the same retinal location on color fundus, 488-R and NIR-R imaging but a different location on AF. The tapetal reflex was most easily detected in 488-R images. The horizontal foveal SD-OCT scans were qualitatively normal, but measurements showed significant outer retinal layer thinning in all eyes. Additionally, the 14 eyes with peripheral SD-OCTs demonstrated patchy loss of the inner segment ellipsoid band. Microperimetry exhibited patchy visual sensitivity loss in 9 eyes. Full field ERGs were variable, ranging from normal to severely abnormal rod and cone responses. Our findings suggest that an optimal protocol for identifying carriers of XLRP should include 488-R imaging in a multimodal approach. Peripheral SD-OCT imaging and central retinal layer quantification revealed significant structural abnormalities.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Optometry and Vision Sciences
Subjects:	R Medicine > RE Ophthalmology
Uncontrolled Keywords:	X-linked retinitis pigmentosa; tapetal-like reflex; spectral domain optical coherence tomograph; scanning laser ophthalmoscope; microperimetry
Publisher:	Elsevier
ISSN:	0014-4835
Last Modified:	24 Oct 2022 11:25
URI:	https://orca.cardiff.ac.uk/id/eprint/48084

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