Hamshere, Marian Lindsay  ORCID: https://orcid.org/0000-0002-8990-0958, Stergiakouli, Evangelia, Langley, Kate ORCID: https://orcid.org/0000-0002-2033-2657, Martin, Joanna ORCID: https://orcid.org/0000-0002-8911-3479, Holmans, Peter Alan ORCID: https://orcid.org/0000-0003-0870-9412, Kent, L., Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862, Gill, M., Thapar, Anita ORCID: https://orcid.org/0000-0002-3689-737X, O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379 and Craddock, Nicholas John ORCID: https://orcid.org/0000-0003-2171-0610
2013.
Shared polygenic contribution between childhood attention-deficit hyperactivity disorder and adult schizophrenia.
British Journal of Psychiatry
203
(2)
, pp. 107-111.
10.1192/bjp.bp.112.117432
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Abstract
Background: There is recent evidence of some degree of shared genetic susceptibility between adult schizophrenia and childhood attention-deficit hyperactivity disorder (ADHD) for rare chromosomal variants. Aims: To determine whether there is overlap between common alleles conferring risk of schizophrenia in adults with those that do so for ADHD in children. Method: We used recently published Psychiatric Genome-wide Association Study (GWAS) Consortium (PGC) adult schizophrenia data to define alleles over-represented in people with schizophrenia and tested whether those alleles were more common in 727 children with ADHD than in 2067 controls. Results: Schizophrenia risk alleles discriminated ADHD cases from controls (P = 1.04 × 10–4, R2 = 0.45%); stronger discrimination was given by alleles that were risk alleles for both adult schizophrenia and adult bipolar disorder (also derived from a PGC data-set) (P = 9.98 × 10–6, R2 = 0.59%). Conclusions: This increasing evidence for a small, but significant, shared genetic susceptibility between adult schizophrenia and childhood ADHD highlights the importance of research work across traditional diagnostic boundaries.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Research Institutes & Centres > MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Schools > Medicine Research Institutes & Centres > Systems Immunity Research Institute (SIURI) Research Institutes & Centres > Neuroscience and Mental Health Research Institute (NMHII) |
| Subjects: | B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| Publisher: | Royal College of Psychiatrists |
| ISSN: | 0007-1250 |
| Funders: | Wellcome Trust, Medical Research Council, NIHR |
| Date of First Compliant Deposit: | 30 March 2016 |
| Last Modified: | 02 Oct 2023 17:29 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/48093 |
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