Intestinal homeostasis and neoplasia studied using conditional transgenesis

Marsh Durban, Victoria ORCID: https://orcid.org/0000-0003-1645-1618 and Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X 2007. Intestinal homeostasis and neoplasia studied using conditional transgenesis. Expert Review of Anticancer Therapy 7 (4) , pp. 519-531. 10.1586/14737140.7.4.519

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Abstract

Constitutive mouse models of intestinal neoplasia, such as the Apcmin/+ (multiple intestinal neoplasia) mouse have proven valuable tools both for furthering our understanding of tumorigenesis and for the development of therapeutic strategies. However, the in vivo study of a number of genes has been precluded by their absolute requirement during embryonic development. This has led to the development of conditional strategies that allow gene regulation in vivo. This review describes the principal techniques used to achieve conditional transgenesis within the mouse intestine, with a particular focus upon the Cre–Lox and Tet-regulable systems. Further, we discuss how these techniques are being used to dissect the mechanisms governing both normal homeostasis and neoplastic development within the intestine.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences European Cancer Stem Cell Research Institute (ECSCRI)
Subjects:	Q Science > QH Natural history > QH301 Biology Q Science > QH Natural history > QH426 Genetics
Uncontrolled Keywords:	bone morphogenic protein: conditional: Cre–Lox: intestine: mouse: neoplasia: Notch; Wnt
Publisher:	Expert Reviews
ISSN:	1473-7140
Last Modified:	24 Oct 2022 11:27
URI:	https://orca.cardiff.ac.uk/id/eprint/48209

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