Transcriptional and post-transcriptional regulation of Drosophila Germline stem cells and their differentiating progeny

White-Cooper, Helen ORCID: https://orcid.org/0000-0002-3373-8023 and Caporilli, Simona 2013. Transcriptional and post-transcriptional regulation of Drosophila Germline stem cells and their differentiating progeny. Hime, Gary and Abud, Helen, eds. Transcriptional and Translational Regulation of Stem Cells, Vol. 1. Advances in Experimental Medicine and Biology, vol. 786. Dordrecht: Springer, pp. 47-61. (10.1007/978-94-007-6621-1_4)

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Abstract

In this chapter we will concentrate on the transcriptional and translational regulations that govern the development and differentiation of male germline cells. Our focus will be on the processes that occur during differentiation, that distinguish the differentiating population of cells from their stem cell parents. We discuss how these defining features are established as cells transit from a stem cell character to that of a fully committed differentiating cell. The focus will be on how GSCs differentiate, via spermatogonia, to spermatocytes. We will achieve this by first describing the transcriptional activity in the differentiating spermatocytes, cataloguing the known tran­scriptional regulators in these cells and then investigating how the transcription programme is set up by processes in the progentior cells. This process is particularly interesting to study from a stem cell perspective as the male GSCs are unipotent, so lineage decisions in differentiating progeny of stem cells, which occurs in many other stem cell systems, do not impinge on the behaviour of these cells.

Item Type:	Book Section
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Subjects:	Q Science > QH Natural history > QH301 Biology Q Science > QH Natural history > QH426 Genetics
Uncontrolled Keywords:	Drosophila; Spermatocyte; Spermatogenesis; Testis; TMAC
Publisher:	Springer
ISBN:	9789400766204
Last Modified:	24 Oct 2022 11:34
URI:	https://orca.cardiff.ac.uk/id/eprint/48603

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