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Increasing complexity of the dystrophin-associated protein complex

Tinsley, Jonathon M, Blake, Derek J., Zuellig, Richard A. and Davies, Kay E. 1994. Increasing complexity of the dystrophin-associated protein complex. Proceedings of the National Academy of Sciences of the United States of America 91 (18) , pp. 8307-8313.

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Duchenne muscular dystrophy is a severe X chromosome-linked, muscle-wasting disease caused by lack of the protein dystrophin. The exact function of dystrophin rem to be determined. However, analysis of its interaction with a large oligomeric protein complex at the sarcolemma and the identicaton of a structurally related protein, utrophin, is leading to the characterization of candidate genes for other neuromuscular disorders.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
Publisher: National Academy of Sciences
ISSN: 0027-8424
Last Modified: 04 Jun 2017 05:12

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