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Impact of interactions between normal and transformed epithelial cells and the relevance to cancer

Hogan, Catherine 2012. Impact of interactions between normal and transformed epithelial cells and the relevance to cancer. Cellular and Molecular Life Sciences 69 (2) , pp. 203-213. 10.1007/s00018-011-0806-3

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The majority of human cancers are initiated when a single cell in an epithelial sheet becomes transformed. Cell transformation arises from the activation of oncoproteins and/or inactivation of tumor suppressor proteins. Recent studies have independently revealed that interaction and communication between transformed cells and their normal neighbors have a significant impact on the fate of the transformed cell. Several reports have shown that various phenomena occur at the interface between normal and transformed epithelial cells following the initial transformation event. In epithelia of Drosophila melanogaster, transformed and normal cells compete for survival in a process termed cell competition. This review will summarize current research and discuss the impact of these studies on our understanding of how primary tumors emerge and develop within a normal epithelium.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
European Cancer Stem Cell Research Institute (ECSCRI)
Subjects: Q Science > QH Natural history > QH301 Biology
R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords: Epithelial cells; Ras; Apical extrusion; Cell competition; Drosophila melanogaster; Field cancerization
Publisher: Springer Verlag
ISSN: 1420-682X
Last Modified: 04 Jun 2017 05:21

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