Nullisomic deletion of the mcf.2 transforming gene in two haemophilia B patients

Anson, D. S., Blake, Derek J. ORCID: https://orcid.org/0000-0002-5005-4731, Winship, P. R., Birnbaum, D. and Brownlee, G. G. 1988. Nullisomic deletion of the mcf.2 transforming gene in two haemophilia B patients. EMBO Journal 7 (9) , pp. 2795-2799.

Full text not available from this repository.

Abstract

The mcf.2 transforming gene sequence has been located to the region between 29 and 61 kb 3' of the factor IX gene. Two unrelated haemophilia B patients who raise antibodies to infused factor IX ('inhibitors') have deletions in excess of 273 kb encompassing the factor IX and mcf.2 genes and a CG-rich island. We believe these patients show the first nullisomic deletion of a transforming gene to be reported. No clinical condition can be attributed to the loss of the mcf.2 gene.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	European Molecular Biology Organization; Nature Publishing Group
ISSN:	0261-4189
Related URLs:	http://www.ncbi.nlm.nih.gov/pubmed/28462...
Last Modified:	25 Oct 2022 08:17
URI:	https://orca.cardiff.ac.uk/id/eprint/52162

Citation Data

Cited 19 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item