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Localization of brain signal sources using blind source separation

Latif, Mohamed Amin 2006. Localization of brain signal sources using blind source separation. PhD Thesis, Cardiff University.

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Abstract

Reliable localization of brain signal sources by using convenient, easy, and hazardless data acquisition techniques can potentially play a key role in the understanding, analysis, and tracking of brain activities for determination of physiological, pathological, and functional abnormalities. The sources can be due to normal brain activities, mental disorders, stimulation of the brain, or movement related tasks. The focus of this thesis is therefore the development of novel source localization techniques based upon EEG measurements. Independent component analysis is used in blind separation (BSS) of the EEG sources to yield three different approaches for source localization. In the first method the sources are localized over the scalp pattern using BSS in various subbands, and by investigating the number of components which are likely to be the true sources. In the second method, the sources are separated and their corresponding topographical information is used within a least-squares algorithm to localize the sources within the brain region. The locations of the known sources, such as some normal brain rhythms, are also utilized to help in determining the unknown sources. The final approach is an effective BSS algorithm partially constrained by information related to the known sources. In addition, some investigation have been undertaken to incorporate non-homogeneity of the head layers in terms of the changes in electrical and magnetic characteristics and also with respect to the noise level within the processing methods. Experimental studies with real and synthetic data sets are undertaken using MATLAB and the efficacy of each method discussed.

Item Type: Thesis (PhD)
Status: Unpublished
Schools: Engineering
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
T Technology > TA Engineering (General). Civil engineering (General)
T Technology > TJ Mechanical engineering and machinery
ISBN: 9781303207570
Date of First Compliant Deposit: 30 March 2016
Last Modified: 12 Feb 2016 23:12
URI: http://orca.cardiff.ac.uk/id/eprint/54567

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