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The synthesis of novel 6-azapyrimidine nucleoside analogues

Jasamai, Malina 2005. The synthesis of novel 6-azapyrimidine nucleoside analogues. PhD Thesis, Cardiff University.

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Abstract

A series of novel acyclic oxonucleoside, 2',3'-dideoxy-4'-thio- and 4'-thio-L-nucleoside analogues have been prepared. An attempt to synthesise the acyclic thio moiety was unsuccessful. The novel analogues synthesised will be evaluated biologically at the Rega Institute in Leuven, Belgium as potential antiviral agents using a wide screen of viral assays including Human Immunodeficiency Virus type 1 and 2 (HIV 1 and HIV 2), Herpes simplex Virus type 1 and 2 (HSV 1 and HSV 2) and Varicella Zoster Virus (VZV).

Item Type: Thesis (PhD)
Status: Unpublished
Schools: Pharmacy
Subjects: R Medicine > RS Pharmacy and materia medica
Date of First Compliant Deposit: 30 March 2016
Last Modified: 12 Feb 2016 23:14
URI: http://orca.cardiff.ac.uk/id/eprint/55438

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