No evidence for a pseudoautosomal locus for schizophrenia. Linkage analysis of multiply affected families

Asherson, Philip, Parfitt, E., Sargeant, M., Tidmarsh, Simon, Buckland, Paul Robert, Taylor, C., Clements, A., Gill, M., McGuffin, Peter and Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862 1992. No evidence for a pseudoautosomal locus for schizophrenia. Linkage analysis of multiply affected families. British Journal of Psychiatry 161 (1) , pp. 63-68. 10.1192/bjp.161.1.63

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Abstract

Evidence for a pseudoautosomal locus for a schizophrenia susceptibility gene was sought by two forms of analysis of 25 multiply affected families. Firstly, in the sample as a whole there was an excess of same-sex over mixed-sex siblings compared with that expected. Secondly, linkage analysis was performed in six of the families. The genotypes were studied for DXYS14, a highly polymorphic marker in the telomeric pseudoautosomal region. No evidence for positive linkage was found with two-point analysis under eight different genetic models for the mode of transmission. A non-parametric, sibling-pair analysis also failed to detect linkage. Our findings provide no evidence for linkage within the pseudoautosomal region; same-sex concordance must arise from some other mechanism.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Research Institutes & Centres > MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Schools > Medicine Research Institutes & Centres > Neuroscience and Mental Health Research Institute (NMHII)
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	Royal College of Psychiatrists
ISSN:	0007-1250
Last Modified:	25 Oct 2022 09:09
URI:	https://orca.cardiff.ac.uk/id/eprint/57450

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