Asherson, Philip, Parfitt, E., Sargeant, M., Tidmarsh, Simon, Buckland, Paul Robert, Taylor, C., Clements, A., Gill, M., McGuffin, Peter and Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862 1992. No evidence for a pseudoautosomal locus for schizophrenia. Linkage analysis of multiply affected families. British Journal of Psychiatry 161 (1) , pp. 63-68. 10.1192/bjp.161.1.63 |
Abstract
Evidence for a pseudoautosomal locus for a schizophrenia susceptibility gene was sought by two forms of analysis of 25 multiply affected families. Firstly, in the sample as a whole there was an excess of same-sex over mixed-sex siblings compared with that expected. Secondly, linkage analysis was performed in six of the families. The genotypes were studied for DXYS14, a highly polymorphic marker in the telomeric pseudoautosomal region. No evidence for positive linkage was found with two-point analysis under eight different genetic models for the mode of transmission. A non-parametric, sibling-pair analysis also failed to detect linkage. Our findings provide no evidence for linkage within the pseudoautosomal region; same-sex concordance must arise from some other mechanism.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI) |
Subjects: | R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
Publisher: | Royal College of Psychiatrists |
ISSN: | 0007-1250 |
Last Modified: | 25 Oct 2022 09:09 |
URI: | https://orca.cardiff.ac.uk/id/eprint/57450 |
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