Changes in dopamine D1, D2 and D3 receptor mRNA levels in rat brain following antipsychotic treatment

Buckland, Paul Robert, O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379 and McGuffin, Peter 1992. Changes in dopamine D1, D2 and D3 receptor mRNA levels in rat brain following antipsychotic treatment. Psychopharmacology 106 (4) , pp. 479-483. 10.1007/BF02244818

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Abstract

The effects of administration of antipsychotic drugs (1–32 days, twice per day) on the rat brain mRNA levels of dopamine D1, D2 and D3 receptors has been assessed by a novel procedure utilising solution hybridisation with oligonucleotides. Saline and sulpiride (10 mg/kg/injection) had no effect on D1, D2 and D3 receptor mRNA levels. Haloperidol (1.5 mg/kg/injection) elicited increases in D1, D2 and D3 receptor mRNA levels of 100%, 100% and 300%, respectively, after 32 days and loxapine (2 mg/kg/injection) elicited increases of 450%, 150% and 550%, respectively. These results indicate that the up-regulation of dopamine receptors may be associated with the occurrence of tardive dyskinesia but not the clinical mode of action of antipsychotics.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Research Institutes & Centres > MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Schools > Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	Springer
ISSN:	0033-3158
Last Modified:	25 Oct 2022 09:11
URI:	https://orca.cardiff.ac.uk/id/eprint/57619

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