A PHABULOSA/cytokinin feedback loop controls root growth in Arabidopsis

Dello Ioio, Raffaele, Galinha, Carla, Fletcher, Alexander G., Grigg, Stephen P., Molnar, Attila, Willemsen, Viola, Scheres, Ben ORCID: https://orcid.org/0000-0001-5400-9578, Sabatini, Sabrina, Baulcombe, David, Maini, Philip K. and Tsiantis, Miltos 2012. A PHABULOSA/cytokinin feedback loop controls root growth in Arabidopsis. Current Biology 22 (18) , pp. 1699-1704. 10.1016/j.cub.2012.07.005

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Abstract

The hormone cytokinin (CK) controls root length in Arabidopsis thaliana by defining where dividing cells, derived from stem cells of the root meristem, start to differentiate [ 1, 2, 3, 4, 5 and 6]. However, the regulatory inputs directing CK to promote differentiation remain poorly understood. Here, we show that the HD-ZIPIII transcription factor PHABULOSA (PHB) directly activates the CK biosynthesis gene ISOPENTENYL TRANSFERASE 7 (IPT7), thus promoting cell differentiation and regulating root length. We further demonstrate that CK feeds back to repress both PHB and microRNA165, a negative regulator of PHB. These interactions comprise an incoherent regulatory loop in which CK represses both its activator and a repressor of its activator. We propose that this regulatory circuit determines the balance of cell division and differentiation during root development and may provide robustness against CK fluctuations.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Subjects:	Q Science > QH Natural history > QH301 Biology
Publisher:	Elsevier
ISSN:	0960-9822
Last Modified:	25 Oct 2022 09:13
URI:	https://orca.cardiff.ac.uk/id/eprint/57684

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