New avenues in the design and potential application of metal complexes for photodynamic therapy

Stacey, Oliver J. and Pope, Simon J. A. ORCID: https://orcid.org/0000-0001-9110-9711 2013. New avenues in the design and potential application of metal complexes for photodynamic therapy. RSC Advances 3 (48) , pp. 25550-25564. 10.1039/c3ra45219k

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Abstract

Photodynamic therapy (PDT) requires a photosensitizing agent, which can undergo visible light activation, yielding reactive oxygen species and/or radical species. The key physical properties and desirable attributes of established PDT photosensitizer agents are discussed, together with a consideration of the role that photoactive metal coordination complexes may have in the future design of such agents. A number of classes of metal complex are included with a focus upon their ability to generate singlet oxygen, and prior indications of biological utility, compatibility and cytotoxicity through cellular imaging work and DNA binding behaviour.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Subjects:	Q Science > QD Chemistry
Publisher:	RSC Publishing
ISSN:	2046-2069
Last Modified:	25 Oct 2022 09:21
URI:	https://orca.cardiff.ac.uk/id/eprint/58143

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