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The pathogenesis of keratoconus

Davidson, A. E., Hayes, Sally, Hardcastle, A. J. and Tuft, S. J. 2013. The pathogenesis of keratoconus. Eye 28 (2) , pp. 189-195. 10.1038/eye.2013.278

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Keratoconus (KC) is a common degenerative condition that frequently results in visual loss with an onset typically in early adulthood. It is the single most common reason for keratoplasty in the developed world. The cause and underlying pathological mechanism are unknown, but both environmental and genetic factors are thought to contribute to the development of the disease. Various strategies have been employed to address the gap in our understanding of this complex disease, with the expectation that over time more sophisticated therapies will be developed. In this review we summarise our current knowledge of the aetiology and risk factors associated with KC.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Optometry and Vision Sciences
Subjects: Q Science > Q Science (General)
Publisher: Nature Publishing Group
ISSN: 0950-222X
Funders: MRC
Date of Acceptance: 20 November 2013
Last Modified: 22 Feb 2019 13:15

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