Llano, I., Gonzalez, J., Caputo, C., Lai, Francis Anthony ORCID: https://orcid.org/0000-0003-2852-8547, Blayney, Lynda Mary, Tan, Y. P. and Marty, A. 2000. Presynaptic calcium stores underlie large-amplitude miniature IPSCs and spontaneous calcium transients. Nature Neuroscience 3 (12) , pp. 1256-1265. 10.1038/81781 |
Abstract
The cellular mechanisms responsible for large miniature currents in some brain synapses remain undefined. In Purkinje cells, we found that large-amplitude miniature inhibitory postsynaptic currents (mIPSCs) were inhibited by ryanodine or by long-term removal of extracellular Ca2+. Two-photon Ca2+ imaging revealed random, ryanodine-sensitive intracellular Ca2+ transients, spatially constrained at putative presynaptic terminals. At high concentration, ryanodine decreased action-potential-evoked rises in intracellular Ca2+. Immuno-localization showed ryanodine receptors in these terminals. Our data suggest that large mIPSCs are multivesicular events regulated by Ca2+ release from ryanodine-sensitive presynaptic Ca2+ stores.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Medicine |
Subjects: | R Medicine > R Medicine (General) |
Additional Information: | There is an Erratum (March 2001) associated with this Article. |
ISSN: | 1097-6256 |
Last Modified: | 13 Dec 2022 09:18 |
URI: | https://orca.cardiff.ac.uk/id/eprint/59389 |
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