A systematic genomewide linkage study in 353 sib pairs with schizophrenia

Williams, Nigel Melville ORCID: https://orcid.org/0000-0003-1177-6931, Norton, Nadine ORCID: https://orcid.org/0000-0002-3848-4288, Williams, Hywel John ORCID: https://orcid.org/0000-0001-7758-0312, Ekholm, B., Hamshere, Marian Lindsay ORCID: https://orcid.org/0000-0002-8990-0958, Lindblom, Y., Chowdari, K. V., Cardno, Alastair George, Zammit, Stanley ORCID: https://orcid.org/0000-0002-2647-9211, Jones, Lisa Anne, Murphy, Kieran Christopher, Sanders, Robert David, McCarthy, Geraldine MaryTeresa, Gray, Marion Yvonne, Jones, G., Holmans, Peter Alan ORCID: https://orcid.org/0000-0003-0870-9412, Nimgaonkar, V., Adolfson, R., Osby, U., Terenius, L., Sedvall, G., O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379 and Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862 2003. A systematic genomewide linkage study in 353 sib pairs with schizophrenia. The American journal of human genetics 73 (6) , pp. 1355-1367. 10.1086/380206

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Abstract

We undertook a genomewide linkage study in a total of 353 affected sib pairs (ASPs) with schizophrenia. Our sample consisted of 179 ASPs from the United Kingdom, 134 from Sweden, and 40 from the United States. We typed 372 microsatellite markers at 10-cM intervals. Our strongest finding was a LOD score of 3.87 on chromosome 10q25.3-q26.3, with positive results being contributed by all three samples and a LOD-1 interval of 15 cM. This finding achieved genomewide significance (P<.05), on the basis of simulation studies. We also found two regions, 17p11.2-q25.1 (maximum LOD score [MLS] = 3.35) and 22q11 (MLS = 2.29), in which the evidence for linkage was highly suggestive. Linkage to all of these regions has been supported by other studies. Moreover, we found strong evidence for linkage (genomewide P<.02) to 17p11.2-q25.1 in a single pedigree with schizophrenia. In our view, the evidence is now sufficiently compelling to undertake detailed mapping studies of these three regions.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Systems Immunity Research Institute (SIURI) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General)
Publisher:	Cell Press
ISSN:	15376605
Last Modified:	01 Dec 2022 09:49
URI:	https://orca.cardiff.ac.uk/id/eprint/610

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