Characterisation of the inflammatory cell infiltrate in chronic hyperplastic candidosis of the oral mucosa

Williams, David Wynne ORCID: https://orcid.org/0000-0002-7351-5131, Potts, Albert John Cornel, Wilson, Melanie ORCID: https://orcid.org/0000-0002-8834-8268, Matthews, John B. and Lewis, Michael Alexander Oxenham ORCID: https://orcid.org/0000-0003-1917-0651 1997. Characterisation of the inflammatory cell infiltrate in chronic hyperplastic candidosis of the oral mucosa. Journal of Oral Pathology & Medicine 26 (2) , pp. 83-89. 10.1111/j.1600-0714.1997.tb00026.x

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Abstract

using immunocytochemical techniques. Nine specimens were stained for human kappa and lambda immunoglobulin light chains, CD68 antigen (macrophages), lysozyme (macrophages, granulocytes), CD3 antigen (T-lymphocytes), CD20 antigen (B-lymphocytes) and leucocyte common antigen (LCA). In addition, these and a further 13 specimens were also examined for immunoglobulin (Ig)-containing cells (IgA, IgG and IgM). The density of the infiltrate varied considerably between cases; T-lymphocytes were the dominant cell type (53.9%), with fewer B-lymphocytes (8.2%) and macrophages (14.2%). Many Ig-containing cells were seen, and although IgG-containing cells predominated, (60.8%, SD +/- 9.0) there was a high proportion of IgA-containing cells (36.7%, SD +/- 9.1) with few IgM-containing cells (2.5%, SD +/- 3.0). Many neutrophils, together with smaller numbers of T-lymphocytes and macrophages, were seen in the epithelium. It is suggested that mucosal defence to Candida infection involves a cell-mediated reaction in which there is recruitment of macrophages and local production of immunoglobulin with a prominent IgA component.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Dentistry
Subjects:	R Medicine > RK Dentistry
Publisher:	John Wiley & Sons
ISSN:	0904-2512
Last Modified:	25 Oct 2022 10:04
URI:	https://orca.cardiff.ac.uk/id/eprint/61075

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