The "window' T-type calcium current in brain dynamics of different behavioural states

Crunelli, Vincenzo ORCID: https://orcid.org/0000-0001-7154-9752, Toth, Tibor I., Cope, David, Blethyn, Kate and Hughes, Stuart W. 2005. The "window' T-type calcium current in brain dynamics of different behavioural states. The Journal of Physiology 562 (1) , pp. 121-129. 10.1113/jphysiol.2004.076273

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Abstract

All three forms of recombinant low voltage-activated T-type Ca2+ channels (Cav3.1, Cav3.2 and Cav3.3) exhibit a small, though clearly evident, window T-type Ca2+ current (ITwindow) which is also present in native channels from different neuronal types. In thalamocortical (TC) and nucleus reticularis thalami (NRT) neurones, and possibly in neocortical cells, an ITwindow-mediated bistability is the key cellular mechanism underlying the expression of the slow (< 1 Hz) sleep oscillation, one of the fundamental EEG rhythms of non-REM sleep. As the ITwindow-mediated bistability may also represent one of the cellular mechanisms underlying the expression of high frequency burst firing in awake conditions, ITwindow is of critical importance in neuronal population dynamics associated with different behavioural states.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Neuroscience and Mental Health Research Institute (NMHRI)
Publisher:	The Physiological Society
ISSN:	0022-3751
Last Modified:	25 Oct 2022 10:05
URI:	https://orca.cardiff.ac.uk/id/eprint/61085

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